Increase in hypoxanthine-guanine phosphoribosyl transferase gene mutations by exposure to high-density 50-Hz magnetic fields

J Miyakoshi; N Yamagishi; S Ohtsu; K Mohri; H Takebe

doi:10.1016/0027-5107(95)00166-2

Increase in hypoxanthine-guanine phosphoribosyl transferase gene mutations by exposure to high-density 50-Hz magnetic fields

Mutat Res. 1996 Jan 17;349(1):109-14. doi: 10.1016/0027-5107(95)00166-2.

Authors

J Miyakoshi¹, N Yamagishi, S Ohtsu, K Mohri, H Takebe

Affiliation

¹ Department of Radiation Genetics, Faculty of Medicine, Kyoto University, Japan. miyakosh@minko.hyg.med.kyoto-u.ac.jp

PMID: 8569782
DOI: 10.1016/0027-5107(95)00166-2

Abstract

Exposure to extremely low frequency magnetic field (ELFMF) of 50 Hz and 400 mT induced mutations in the hypoxanthine-guanine phosphoribosyl transferase gene of human melanoma MeWo cells. The mutant frequency was enhanced both by increasing the exposure period and the induced current intensity. Mutations induced by X-rays were enhanced by ELFMF exposure. No significant increase in mutant frequency occurred when DNA replication was inhibited during ELFMF exposure. DNA replication error is suspected of causing the mutations produced by ELFMF exposure.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Division
Cell Survival
DNA / radiation effects
Humans
Hypoxanthine Phosphoribosyltransferase / genetics*
Magnetics*
Mutagenesis*
Tumor Cells, Cultured

Substances

DNA
Hypoxanthine Phosphoribosyltransferase