A-72363 A-1, A-2 and C, novel heparanase inhibitors from Streptomyces nobilis SANK 60192. I. Taxonomy of producing organism, fermentation, isolation and structure elucidation

J Antibiot (Tokyo). 1996 Jan;49(1):54-60. doi: 10.7164/antibiotics.49.54.

Abstract

Novel heparanse inhibitors, A72363 A-1, A-2, and C, were isolated from the culture filtrate of Streptomyces nobilis SANK 60192 by column chromatography on various resinous adsorbents, followed by preparative anion exchange HPLC. Spectroscopic studies revealed that they are diastereomers of siastatin B, a neuraminidase inhibitor.

MeSH terms

  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Fermentation*
  • Glucuronidase*
  • Glycoside Hydrolases / antagonists & inhibitors*
  • Piperidines / chemistry
  • Piperidines / isolation & purification*
  • Streptomyces / classification
  • Streptomyces / metabolism*

Substances

  • Enzyme Inhibitors
  • Piperidines
  • siastatin
  • Glycoside Hydrolases
  • heparanase
  • Glucuronidase