In-vitro susceptibility of Streptococcus pneumoniae to the d- and l-isomers of ofloxacin: interpretive criteria and quality control limits

J Antimicrob Chemother. 1996 Feb;37(2):365-9. doi: 10.1093/jac/37.2.365.

Abstract

The l-isomer of ofloxacin (levofloxacin) was twice as active as ofloxacin and the d-isomer was inactive against 654 Streptococcus pneumoniae isolates. For disc susceptibility tests of pneumococci, 5 micrograms levofloxacin discs can be used with interpretive criteria of < or = 12 mm for resistant (MIC > or = 8.0 mg/L) and > or = 16 mm for susceptible (MIC < or = 2.0 mg/L). For quality control of levofloxacin tests, S. pneumoniae ATCC 49619 should give zones 20-25 mm in diameter and MICs 0.5-2.0 mg/L.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / pharmacology*
  • Data Interpretation, Statistical
  • Levofloxacin*
  • Microbial Sensitivity Tests
  • Ofloxacin / pharmacology*
  • Quality Control
  • Reproducibility of Results
  • Stereoisomerism
  • Streptococcus pneumoniae / drug effects*

Substances

  • Anti-Infective Agents
  • Levofloxacin
  • Ofloxacin