Objective: To review fifteen cases with primary malignant lymphoma of the female genital tract at Cancer Hospital, Chinese Academy of Medical Sciences from 1980 approximately 1994.
Methods: This is a clinical retrospective analysis. There were 7 cases of lymphoma originating in the cervix, 2 in the vagina, 3 in the ovary, 1 in the vulva, endometrium and pelvic cavity respectively. All of the 15 cases were given combination therapy. 3 ovarian lymphoma were treated by surgery and chemotherapy, 2 cervical lymphoma and 1 endometrial lymphoma by surgery, chemotherapy and radiotherapy, 1 pelvic lymphoma by surgery and radiotherapy, others by radiotherapy and chemotherapy.
Results: Two patients are living more than 5 years, 3 patients more than 3 years. 4 patients were followed up for less than 2 years and 6 patients relapsed or died.
Conclusions: The prognosis of ovarian lymphoma is worse than that of other genital sites. Combined and sequential chemotherapy-radiotherapy-chemotherapy is the proper treatment sequence for lymphoma of the cervix, vagina and vulva. Extensive chemotherapy may be an appropriate choice for highly malignant pathological type. Radiation should be given early for large cervical lymphoma.