Abstract
Yeast has a rigid cell wall comprising an outer layer of glycoproteins and an internal skeletal layer of glucan; heterologous proteins can be targeted to the glycoprotein layer and become covalently linked to the glucan skeleton. Yeast is a eukaryote that has 'generally regarded as safe' (GRAS) status, and is easy to cultivate, so it seems ideally suited for applications including the manufacture of recyclable, immobilized, biocatalysts, whole-cell vaccines, the presentation of peptide or antibody libraries, and the presentation of adhesion or metal-binding proteins.
MeSH terms
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Administration, Oral
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Antibodies / genetics
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Antibodies / metabolism
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Biodegradation, Environmental
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Biotechnology / trends
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Cell Membrane / metabolism*
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Enzymes, Immobilized
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Gene Expression
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Mannose-Binding Lectins
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Mating Factor
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Membrane Proteins / metabolism
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Peptides / metabolism
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Recombinant Fusion Proteins / genetics
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Recombinant Fusion Proteins / metabolism*
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / metabolism*
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Saccharomyces cerevisiae Proteins*
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Vaccines / administration & dosage
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Vaccines / isolation & purification
Substances
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Antibodies
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Enzymes, Immobilized
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FLO1 protein, S cerevisiae
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Mannose-Binding Lectins
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Membrane Proteins
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Peptides
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Recombinant Fusion Proteins
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Saccharomyces cerevisiae Proteins
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Vaccines
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Mating Factor