Double-blind controlled trial of sertraline versus paroxetine in the treatment of delusional depression

Am J Psychiatry. 1996 Dec;153(12):1631-3. doi: 10.1176/ajp.153.12.1631.

Abstract

Objective: In this study the authors evaluated the efficacy and the tolerability of sertraline and paroxetine in the treatment of delusional depression.

Method: Under double-blind conditions, 46 hospitalized patients who met the DSM-III-R criteria for major depression with psychotic features were treated with sertraline or paroxetine for 6 weeks.

Results: The response rates were 75% and 46% for sertraline and paroxetine, respectively. The dropout rate was substantial (41%) in the paroxetine group and was attributable to side effects.

Conclusions: Selective serotonin reuptake inhibitors administered alone are useful in the treatment of delusional depression.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • 1-Naphthylamine / administration & dosage
  • 1-Naphthylamine / analogs & derivatives*
  • 1-Naphthylamine / therapeutic use
  • Delusions / drug therapy*
  • Delusions / psychology
  • Depressive Disorder / drug therapy*
  • Depressive Disorder / psychology
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Hospitalization
  • Humans
  • Male
  • Middle Aged
  • Paroxetine / administration & dosage
  • Paroxetine / therapeutic use*
  • Selective Serotonin Reuptake Inhibitors / administration & dosage
  • Selective Serotonin Reuptake Inhibitors / therapeutic use*
  • Sertraline
  • Treatment Outcome

Substances

  • Serotonin Uptake Inhibitors
  • Paroxetine
  • 1-Naphthylamine
  • Sertraline