Brasiliquinones A, B and C, new benz[alpha]anthraquinone antibiotics from Nocardia brasiliensis. I. Producing strain, isolation and biological activities of the antibiotics

J Antibiot (Tokyo). 1997 Jan;50(1):18-21. doi: 10.7164/antibiotics.50.18.

Abstract

New benz[alpha]anthraquinone antibiotics (brasiliquinones A, B and C) with an ethyl group at C-3 were isolated. The producer was identified as Nocardia brasiliensis. The antibiotics were active against Gram-positive bacteria including Mycobacterium sp., but not active against Gram-negative bacteria or fungi. They were also active against multiple drug-resistant P388/ADR tumor cells.

MeSH terms

  • Animals
  • Anthraquinones / isolation & purification
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Fermentation
  • Mice
  • Nocardia / classification
  • Nocardia / metabolism*
  • Tumor Cells, Cultured

Substances

  • Anthraquinones
  • Anti-Bacterial Agents
  • brasiliquinone A
  • brasiliquinone B
  • brasiliquinone C