Objective: To investigate the incidence of ovarian metastasis in cervical cancer, especially in early FIGO stages.
Methods: Seventeen cervical cancer patients with ovarian metastasis treated at Cancer Hospital, Chinese Academy of Medical Sciences from 1958 to 1994 were retrospectively analysed. The diagnoses of all patients were confirmed by operations and pathologic examinations.
Results: The incidence of ovarian metastasis in cervical cancer was 0.07% in squamous cell carcinoma and 1.81% in adenocarcinoma (P < 0.05). In early stages (stage l-I), the incidence of ovarian metastasis in adenocarcinoma was higher than that in squamous cell carcinoma (2.2% VS 0.08%, P < 0.05). In patients treated by surgery, the rate of ovarian metastasis in adenocarcinoma was also higher than that in squamous cell carcinoma (7.8% VS 1.6%, P < 0.05). 10 of the 17 cases had macroscopic metastasis and 7 had microscopic metastasis. 11 patients (58.8%) were with bilateral ovarian involvement. Uterine corpus invasion and retroperitoneal lymph node involvements were high risk factors for ovarian metastasis in cervical cancer. The prognosis of cervical cancer patients with ovarian metastasis was poor, the 5-year survival rate in this study being only 17.6%.
Conclusions: Patients with cervical cancer are threatened with the risk of ovarian metastasis, especially in adenocarcinoma. Conservative treatment of the cervical cancer with reservation of the ovary should be further investigated.