Abstract
L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / therapeutic use*
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Antifungal Agents / therapeutic use*
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Candida albicans / drug effects
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Candidiasis / drug therapy*
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Caspofungin
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Echinocandins
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Lipopeptides
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Male
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Mice
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Mice, Inbred ICR
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Peptides*
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Peptides, Cyclic*
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Peptides
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Peptides, Cyclic
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Caspofungin