DBT: a partial D phenotype associated with the low-incidence antigen Rh32

Transfus Med. 1997 Sep;7(3):233-8. doi: 10.1046/j.1365-3148.1997.d01-32.x.

Abstract

Eight probands are described with a D phenotype in which a partial D antigen is associated with Rh32 antigen; three of these probands were investigated because of the anti-D in their serum. The partial D lacks epD1-epD5 and epD9 and some epD6/7 and only expresses epD8 and other parts of epD6/7. The strength of the partial D antigen varies between unrelated DBT individuals. The Rh32 antigen of the DBT cells is weaker than that of D(C)(e) cells. Tests on DBT, DFR and R0Har cells with anti-epD6/7 split these monoclonal anti-D into eight patterns of reaction. A new pattern of reactions was observed, presaging a new epitope, but this was not numbered.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Monoclonal
  • Female
  • Humans
  • Incidence
  • Pedigree
  • Phenotype
  • Rh-Hr Blood-Group System / genetics*

Substances

  • Antibodies, Monoclonal
  • Rh-Hr Blood-Group System
  • Rho(D) antigen