A protein particle vaccine containing multiple malaria epitopes

Nat Biotechnol. 1997 Nov;15(12):1280-4. doi: 10.1038/nbt1197-1280.

Abstract

Ty virus-like particles consist of a single protein species that can be produced in yeast. Recombinant Ty-VLPs carrying a string of up to 15 defined cytotoxic T lymphocyte (CTL) epitopes from Plasmodium species prime protective CTL responses in mice following a single administration without adjuvant. Effective processing of epitopes from the string was demonstrated in vitro and in vivo and was not affected by flanking sequences.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Epitopes / chemistry*
  • Epitopes / immunology
  • Female
  • Humans
  • Malaria Vaccines / chemistry*
  • Malaria Vaccines / immunology
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Plasmodium berghei / immunology
  • Plasmodium falciparum / immunology*
  • T-Lymphocytes, Cytotoxic / immunology

Substances

  • Epitopes
  • Malaria Vaccines