Haemodynamic responses to sevoflurane compared with halothane during inhalational induction in children

Paediatr Anaesth. 1997;7(6):439-44. doi: 10.1046/j.1460-9592.1997.d01-124.x.

Abstract

We studied the haemodynamic changes during induction of anaesthesia in 50 ASA I and II children (1-12 yrs) undergoing minor elective surgery. The patients were randomly divided into two groups to receive either halothane (n = 25) or sevoflurane (n = 25) in a mixture of O2 and N2O (40:60) for mask induction of anaesthesia. Induction of anaesthesia was performed with an overpressure technique by administering rapid increases of gas concentrations, in increments of 1% up to 7% for sevoflurane and of 0.5% up to 3% for halothane. Induction was smooth and rapid in both groups but characterized by increases in heart rate and systolic blood pressure up to 20% especially in the sevoflurane group (P < 0.05); these increases in the latter group were significant compared with baseline and the halothane group (P < 0.05). No serious complications were observed. The authors conclude that more children experienced heart rate and blood pressure increases during the early stage of inhalational induction with sevoflurane compared with halothane.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Analysis of Variance
  • Anesthesia, Inhalation*
  • Anesthetics, Inhalation / administration & dosage*
  • Blood Pressure / drug effects*
  • Carbon Dioxide / metabolism
  • Chi-Square Distribution
  • Child
  • Child, Preschool
  • Elective Surgical Procedures
  • Ethers / administration & dosage*
  • Female
  • Halothane / administration & dosage*
  • Heart Rate / drug effects*
  • Humans
  • Infant
  • Male
  • Methyl Ethers*
  • Minor Surgical Procedures
  • Multivariate Analysis
  • Nitrous Oxide / administration & dosage
  • Oxygen / administration & dosage
  • Oxygen / blood
  • Respiration / drug effects
  • Sevoflurane
  • Tidal Volume

Substances

  • Anesthetics, Inhalation
  • Ethers
  • Methyl Ethers
  • Carbon Dioxide
  • Sevoflurane
  • Nitrous Oxide
  • Oxygen
  • Halothane