Human papillomavirus infection in squamous cell carcinoma of the vulva, in various synchronous epithelial changes and in normal vulvar skin

M J Kagie; G G Kenter; Y Zomerdijk-Nooijen; J Hermans; E Schuuring; P J Timmers; J B Trimbos; G J Fleuren

doi:10.1006/gyno.1997.4834

Human papillomavirus infection in squamous cell carcinoma of the vulva, in various synchronous epithelial changes and in normal vulvar skin

Gynecol Oncol. 1997 Nov;67(2):178-83. doi: 10.1006/gyno.1997.4834.

Authors

M J Kagie¹, G G Kenter, Y Zomerdijk-Nooijen, J Hermans, E Schuuring, P J Timmers, J B Trimbos, G J Fleuren

Affiliation

¹ Department of Gynecology, Leiden University Medical Center, The Hague, 2501 CK, The Netherlands.

PMID: 9367704
DOI: 10.1006/gyno.1997.4834

Abstract

Objective: To investigate the prevalence of human papillomavirus (HPV) infection in various vulvar lesions.

Methods: HPV infection using consensus primer-PCR was studied in 66 patients with vulvar carcinoma and in the synchronous epithelial lesions.

Results: HPV infection was present in 13/66 carcinoma, in 1/33 VIN I, in 3/11 VIN II, in 8/16 VIN III, in 2/30 lichen sclerosus, in 1/37 squamous cell hyperplasia, and in 2/55 normal skin specimens. Normal skin from healthy controls showed HPV-negative specimens only. Patients with HPV-positive carcinomas were younger, presented in lower stages, and had high-grade VIN more often than those with HPV-negative carcinomas.

Conclusions: In sum we found that all types of epithelial changes synchronous with carcinoma of the vulva showed HPV infection, indicating that they all might have malignant potential.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell / pathology
Carcinoma, Squamous Cell / virology*
Female
Humans
Middle Aged
Papillomaviridae / isolation & purification*
Papillomavirus Infections / virology*
Tumor Virus Infections / virology*
Vulva / virology
Vulvar Neoplasms / pathology
Vulvar Neoplasms / virology*