Lack of association between human leukocyte antigens and the anti-Hu syndrome in patients with small-cell lung cancer

Neurology. 1998 Feb;50(2):565-6. doi: 10.1212/wnl.50.2.565.

Abstract

We compared the human leukocyte antigen alleles found in a group of 17 patients with small-cell lung cancer (SCLC), paraneoplastic neurologic syndromes (PNS), and high titers of anti-Hu autoantibodies with those in 30 patients with SCLC but no PNS and no anti-Hu antibodies (control group). There was no difference between the two groups, suggesting that specific haplotypes are not required for the development of the "anti-Hu syndrome."

Publication types

  • Comparative Study

MeSH terms

  • Alleles
  • Autoantibodies / blood*
  • Autoimmune Diseases / immunology*
  • Carcinoma, Small Cell / genetics
  • Carcinoma, Small Cell / immunology*
  • Cytotoxicity, Immunologic
  • HLA-A Antigens / genetics
  • HLA-B Antigens / genetics
  • HLA-DR Antigens / genetics
  • HLA-DRB1 Chains
  • Histocompatibility Testing
  • Humans
  • Lung Neoplasms / genetics
  • Lung Neoplasms / immunology*
  • Nervous System Diseases / genetics
  • Nervous System Diseases / immunology*
  • Paraneoplastic Syndromes / immunology*

Substances

  • Autoantibodies
  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-DR Antigens
  • HLA-DRB1 Chains