Brasilinolide A, a new macrolide antibiotic produced by Nocardia brasiliensis: producing strain, isolation and biological activity

Y Tanaka; H Komaki; K Yazawa; Y Mikami; A Nemoto; T Tojyo; K Kadowaki; H Shigemori; J Kobayashi

doi:10.7164/antibiotics.50.1036

Brasilinolide A, a new macrolide antibiotic produced by Nocardia brasiliensis: producing strain, isolation and biological activity

J Antibiot (Tokyo). 1997 Dec;50(12):1036-41. doi: 10.7164/antibiotics.50.1036.

Authors

Y Tanaka¹, H Komaki, K Yazawa, Y Mikami, A Nemoto, T Tojyo, K Kadowaki, H Shigemori, J Kobayashi

Affiliation

¹ Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.

PMID: 9510911
DOI: 10.7164/antibiotics.50.1036

Abstract

A new 32-membered macrolide antibiotic, brasilinolide A was isolated from the fermentation broth of Nocardia sp. IFM 0406. The producer was identified as Nocardia brasiliensis. The antibiotic was only active against Aspergillus niger, but not active against other fungi including yeasts as well as other filamentous like fungi and bacteria. Brasilinolide A exerted an immunosuppressive activity in the assay system of a mixed lymphocyte reaction (MLR).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Bacterial Agents / biosynthesis
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Bacteria / drug effects
Cells, Cultured / drug effects
Culture Media
Fungi / drug effects
HeLa Cells / drug effects
Humans
Macrolides / chemistry*
Macrolides / isolation & purification*
Macrolides / pharmacology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Nocardia / chemistry*
Nocardia / classification

Substances

Anti-Bacterial Agents
Culture Media
Macrolides
brasilinolide A