Abstract
Euchromatic genes are often silenced by rearrangements that place them within or near heterochromatin, a phenomenon known as position effect variegation (PEV). However, little is known about molecular structure of cis-acting heterochromatic fragments responsible for PEV. Here we report that heterochromatic cluster containing Stellate repeats, that encode putative regulatory subunit of protein kinase CK2 cause PEV of a reporter white 'mini-gene'. It is the first example of an euchromatic gene being silenced because of the proximity to the natural, well-defined heterochromatic repeat cluster.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Casein Kinase II
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Chromatin / genetics*
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Drosophila / genetics*
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Drosophila Proteins
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Euchromatin
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Eye / growth & development
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Gene Expression Regulation, Developmental / genetics
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Genes, Insect / genetics
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Genes, Regulator / genetics
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Heterochromatin / genetics*
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Insect Proteins / genetics*
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Pigmentation / genetics
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Protein Kinases*
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Protein Serine-Threonine Kinases / genetics
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Repetitive Sequences, Nucleic Acid / genetics
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Transformation, Genetic
Substances
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Chromatin
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Drosophila Proteins
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Euchromatin
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Heterochromatin
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Insect Proteins
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Protein Kinases
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Casein Kinase II
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Protein Serine-Threonine Kinases
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Ste protein, Drosophila