Cytotoxic compounds from the roots of Juglans mandshurica

J Nat Prod. 1998 May;61(5):643-5. doi: 10.1021/np970413m.

Abstract

Three new compounds, a diarylheptanone glucoside (1), 4,5, 8-trihydroxy-alpha-tetralone 5-O-beta-d-[6'-O-(3", 5"-dimethoxy-4"-hydroxybenzoyl)]glucopyranoside (2), and 1,4, 8-trihydroxy-3-naphthalenecarboxylic acid 1-O-beta-d-glucopyranoside methyl ester (3), were isolated from the roots of Juglans mandshurica, and their structures were elucidated on the basis of spectroscopic studies including 2D-NMR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Bridged-Ring Compounds / chemistry
  • Bridged-Ring Compounds / isolation & purification*
  • Diarylheptanoids*
  • Drug Screening Assays, Antitumor
  • Glucosides / chemistry
  • Glucosides / isolation & purification*
  • Humans
  • Naphthalenes / chemistry
  • Naphthalenes / isolation & purification*
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Spectrum Analysis
  • Tetralones*
  • Tumor Cells, Cultured

Substances

  • 1,4,8-trihydroxy-3-naphthalenecarboxylic acid 1-O-glucopyranoside methyl ester
  • 4,5,8-trihydroxy-alpha-tetralone 5-O-(6'-O-(3'',5''-dimethoxy-4''-hydroxybenzoyl))glucopyranoside
  • Antineoplastic Agents, Phytogenic
  • Bridged-Ring Compounds
  • Diarylheptanoids
  • Glucosides
  • Naphthalenes
  • Tetralones
  • diarylheptanone glucoside I