Downregulation of PS1 expression in neurons decreases beta-amyloid production: a biochemical link between the two major familial Alzheimer's disease genes

Mol Psychiatry. 1998 Jul;3(4):287-9. doi: 10.1038/sj.mp.4000408.
No abstract available

Publication types

  • News

MeSH terms

  • Alzheimer Disease / genetics*
  • Alzheimer Disease / metabolism
  • Amyloid beta-Peptides / biosynthesis*
  • Amyloid beta-Peptides / genetics*
  • Amyloid beta-Protein Precursor / chemistry
  • Amyloid beta-Protein Precursor / genetics
  • Animals
  • Brain / metabolism*
  • Chromosomal Proteins, Non-Histone / biosynthesis
  • Chromosomal Proteins, Non-Histone / chemistry
  • Chromosomal Proteins, Non-Histone / genetics*
  • Gene Expression Regulation*
  • Humans
  • Mice
  • Mice, Knockout
  • Neurons / metabolism*

Substances

  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Chromosomal Proteins, Non-Histone