Abstract
The bis-naphthalimide DMP 840 has demonstrated high level antitumor activity in a number of preclinical models and has been evaluated in several Phase I studies in adults. We enrolled 10 patients with refractory pediatric solid tumors to this Phase I study of DMP 840 given intravenously by short infusion daily for 5 days. The most frequent and dose-limiting toxicity was myelosuppression. The maximum tolerated dose on this schedule was 8.6 mg/m2 daily for 5 days. One patient had a complete response; there were no measurable tumor responses among the remaining 9 patients.
Publication types
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Clinical Trial
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Clinical Trial, Phase I
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / adverse effects*
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Antineoplastic Agents / therapeutic use
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Child
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Child, Preschool
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Humans
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Isoquinolines / administration & dosage
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Isoquinolines / adverse effects*
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Isoquinolines / therapeutic use
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Mesylates / administration & dosage
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Mesylates / adverse effects*
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Mesylates / therapeutic use
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Neoplasms / drug therapy*
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Thrombocytopenia / chemically induced
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Treatment Outcome
Substances
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Antineoplastic Agents
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Isoquinolines
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Mesylates
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bisnafide