Abstract
The antidepressant activities of mianserin hydrochloride were investigated and compared with those of amitriptyline. The therapeutic efficacy of the two drugs appeared similar, but the incidence of side-effects was significantly higher with amitriptyline. Plasma levels of mianserin were determined during the trial and were not related to the therapeutic activity of the drug.
MeSH terms
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Adjustment Disorders / drug therapy
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Amitriptyline / adverse effects
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Amitriptyline / blood
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Amitriptyline / therapeutic use
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Depression / drug therapy*
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Dibenzazepines / therapeutic use*
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Drug Evaluation
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Female
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Humans
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Male
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Mianserin / adverse effects
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Mianserin / blood
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Mianserin / therapeutic use*
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Middle Aged
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Time Factors
Substances
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Dibenzazepines
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Amitriptyline
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Mianserin