Fulminant hepatic failure secondary to herpes simplex virus infection in a neonate: A case report of successful treatment with liver transplantation and perioperative acyclovir

Liver Transpl Surg. 1998 Nov;4(6):513-5. doi: 10.1002/lt.500040601.

Abstract

Neonatal disseminated herpes simplex virus (HSV) infection, including fulminant hepatic failure (FHF), is lethal, and the patients rarely have a chance for liver transplantation because of the rapid development of the disease. We describe of a case of FHF secondary to HSV infection in a neonate successfully treated by aggressive intensive care followed by liver transplantation.

Publication types

  • Case Reports

MeSH terms

  • Acyclovir / therapeutic use*
  • Antiviral Agents / therapeutic use*
  • Cytomegalovirus Infections / complications
  • Cytomegalovirus Infections / drug therapy
  • Female
  • Hepatic Encephalopathy / etiology*
  • Hepatic Encephalopathy / surgery*
  • Herpes Simplex / complications*
  • Herpes Simplex / drug therapy*
  • Humans
  • Infant, Newborn
  • Liver Transplantation*
  • Polymerase Chain Reaction

Substances

  • Antiviral Agents
  • Acyclovir