Efficient induction of protective anti-malaria immunity by recombinant adenovirus

Vaccine. 1998 Nov;16(19):1812-7. doi: 10.1016/s0264-410x(98)00181-9.

Abstract

The immunogenicity of a previously constructed replication-defective recombinant adenovirus expressing the CS protein of Plasmodium yoelii was compared with that of irradiated sporozoites. We found that immunization of BALB/c mice with a single dose of this recombinant adenovirus induced a much greater CS-specific T-cell response compared with immunization with irradiated sporozoites. More importantly, we found that this recombinant adenovirus induces similar or higher levels of protective immunity than those induced by irradiated sporozoites, eliciting an appreciable resistance to malaria infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenoviridae / genetics
  • Adenoviridae / immunology
  • Adenoviridae / metabolism
  • Amino Acid Sequence
  • Animals
  • CD4-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • Female
  • Liver / parasitology
  • Lymphocyte Activation / immunology
  • Malaria / immunology*
  • Malaria / prevention & control*
  • Malaria Vaccines / genetics
  • Malaria Vaccines / immunology
  • Malaria Vaccines / therapeutic use*
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Plasmodium yoelii / genetics
  • Plasmodium yoelii / immunology*
  • Protozoan Proteins / biosynthesis
  • Protozoan Proteins / genetics
  • Protozoan Proteins / immunology*

Substances

  • Malaria Vaccines
  • Protozoan Proteins
  • circumsporozoite protein, Protozoan