A comparison of three fluid-vasopressor regimens used to prevent hypotension during subarachnoid anaesthesia in the elderly

Anaesth Intensive Care. 1998 Oct;26(5):497-502. doi: 10.1177/0310057X9802600504.

Abstract

We aimed to compare the efficacy of fluid preloading with two recently recommended fluid-vasopressor regimens for maintaining blood pressure during subarachnoid anaesthesia in the elderly. Sixty elderly patients requiring surgery for traumatic hip fractures received subarachnoid anaesthesia using 0.05 ml/kg of 0.5% heavy bupivacaine. Hypotension, i.e. systolic arterial pressure < 75% of baseline, was prevented or treated by: A--normal saline 16 ml/kg plus intravenous ephedrine boluses (0.1 mg/kg); B--normal saline 8 ml/kg plus intramuscular depot ephedrine (0.5 mg/kg); or C--Haemaccel 8 ml/kg plus metaraminol infusion. Systolic arterial pressure and heart rate were recorded using custom-written computer software (Monitor, version 1.0). Systolic arterial pressure decreased in all groups after five minutes (P < 0.001). Decreases were greatest in group A (P < 0.05). Heart rate increased by 7% group A and decreased by 9% in group C (P < 0.05). During the first hour, hypotension was present for 47%, 25% and 20% of the time in groups A, B and C respectively and overcorrection of systolic arterial pressure occurred in 19% of the time in group C. We conclude that treatment A was inadequate in preventing hypotension. Treatments B and C were more effective but were associated with an increased heart rate and overcorrection of systolic arterial pressure respectively.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anesthesia, Spinal*
  • Ephedrine / administration & dosage
  • Ephedrine / therapeutic use*
  • Female
  • Femoral Neck Fractures / surgery
  • Humans
  • Hypotension / prevention & control*
  • Intraoperative Complications / prevention & control*
  • Male
  • Metaraminol / administration & dosage
  • Metaraminol / therapeutic use*
  • Plasma Substitutes / administration & dosage
  • Polygeline / administration & dosage
  • Sodium Chloride / administration & dosage
  • Vasoconstrictor Agents / administration & dosage
  • Vasoconstrictor Agents / therapeutic use*

Substances

  • Plasma Substitutes
  • Vasoconstrictor Agents
  • Sodium Chloride
  • Metaraminol
  • Polygeline
  • Ephedrine