New secosteroids from a gorgonian of the genus Muricella

J Nat Prod. 1998 Nov;61(11):1441-3. doi: 10.1021/np980220e.

Abstract

Calicoferols F-I (2-5), four new 9,10-secosteroids, have been isolated from a gorgonian of the genus Muricella collected from Jaeju Island, Korea. The structures of these compounds have been determined by combined spectroscopic methods. Calicoferols exhibited significant cytotoxicity and inhibitory activity against PLA2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cnidaria / chemistry*
  • Drug Screening Assays, Antitumor
  • Korea
  • Magnetic Resonance Spectroscopy
  • Phospholipases A / antagonists & inhibitors
  • Phospholipases A2
  • Secosteroids / isolation & purification*
  • Secosteroids / pharmacology
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • Secosteroids
  • Phospholipases A
  • Phospholipases A2