Abstract
Forty-eight patients with advanced head and neck tumours were treated with irradiation and concomitant chemotherapy with cisplatin, vindesine and hyaluronidase. The disease-free survival rate at 5 years was 47%. The toxic effects were mucositis (48 patients), nausea (25 patients, vomiting in six patients), bone marrow depression (15 patients) and peripheral neuropathy (14 patients). The results warrant a randomized trial.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Carcinoma, Squamous Cell / drug therapy*
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Carcinoma, Squamous Cell / mortality
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Carcinoma, Squamous Cell / radiotherapy
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Cisplatin / administration & dosage
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Head and Neck Neoplasms / drug therapy*
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Head and Neck Neoplasms / mortality
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Head and Neck Neoplasms / radiotherapy
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Humans
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Hyaluronoglucosaminidase / administration & dosage
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Survival Rate
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Vindesine / administration & dosage
Substances
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Hyaluronoglucosaminidase
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Cisplatin
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Vindesine