Hyaluronidase as additive to induction chemotherapy in advanced squamous cell carcinoma of the head and neck

Cancer Lett. 1998 Sep 11;131(1):113-5. doi: 10.1016/s0304-3835(98)00207-9.

Abstract

Forty-eight patients with advanced head and neck tumours were treated with irradiation and concomitant chemotherapy with cisplatin, vindesine and hyaluronidase. The disease-free survival rate at 5 years was 47%. The toxic effects were mucositis (48 patients), nausea (25 patients, vomiting in six patients), bone marrow depression (15 patients) and peripheral neuropathy (14 patients). The results warrant a randomized trial.

Publication types

  • Clinical Trial

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Carcinoma, Squamous Cell / drug therapy*
  • Carcinoma, Squamous Cell / mortality
  • Carcinoma, Squamous Cell / radiotherapy
  • Cisplatin / administration & dosage
  • Head and Neck Neoplasms / drug therapy*
  • Head and Neck Neoplasms / mortality
  • Head and Neck Neoplasms / radiotherapy
  • Humans
  • Hyaluronoglucosaminidase / administration & dosage
  • Survival Rate
  • Vindesine / administration & dosage

Substances

  • Hyaluronoglucosaminidase
  • Cisplatin
  • Vindesine