Abstract
Melanogenesis generates immunosuppressive and mutagenic environment and alters cellular metabolism. Melanin can protect malignant melanocytes against chemo-, radio-, and photodynamic therapy. Therefore, we propose to inhibit melanogenesis as an adjuvant treatment modality during immuno-, radio-, chemo- and photodynamic therapy, and as a measure of reducing the probability of melanoma progression.
MeSH terms
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Antimetabolites, Antineoplastic / therapeutic use
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Bromodeoxyuridine / therapeutic use
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Chemotherapy, Adjuvant / methods*
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Humans
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Melanins / biosynthesis*
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Melanins / pharmacology
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Melanocytes / drug effects*
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Melanoma / drug therapy*
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Melanoma / radiotherapy
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Melanoma / therapy
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Photochemotherapy
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Protective Agents / pharmacology
Substances
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Antimetabolites, Antineoplastic
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Melanins
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Protective Agents
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Bromodeoxyuridine