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Replication of Plasmodium in reticulocytes can occur without hemozoin formation, resulting in chloroquine resistance.
Lin JW, Spaccapelo R, Schwarzer E, Sajid M, Annoura T, Deroost K, Ravelli RB, Aime E, Capuccini B, Mommaas-Kienhuis AM, O'Toole T, Prins F, Franke-Fayard BM, Ramesar J, Chevalley-Maurel S, Kroeze H, Koster AJ, Tanke HJ, Crisanti A, Langhorne J, Arese P, Van den Steen PE, Janse CJ, Khan SM. Lin JW, et al. Among authors: spaccapelo r. J Exp Med. 2015 Jun 1;212(6):893-903. doi: 10.1084/jem.20141731. Epub 2015 May 4. J Exp Med. 2015. PMID: 25941254 Free PMC article.
Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria.
Spaccapelo R, Janse CJ, Caterbi S, Franke-Fayard B, Bonilla JA, Syphard LM, Di Cristina M, Dottorini T, Savarino A, Cassone A, Bistoni F, Waters AP, Dame JB, Crisanti A. Spaccapelo R, et al. Am J Pathol. 2010 Jan;176(1):205-17. doi: 10.2353/ajpath.2010.090504. Epub 2009 Dec 17. Am J Pathol. 2010. PMID: 20019192 Free PMC article.
71 results