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Tissue distribution and retention drives efficacy of rapidly clearing VHL-based PROTACs.
Zhang D, Ma B, Dragovich PS, Ma L, Chen S, Chen EC, Ye X, Liu J, Pizzano J, Bortolon E, Chan E, Zhang X, Chen YC, Levy ES, Yauch RL, Khojasteh SC, Hop CECA. Zhang D, et al. Among authors: hop ceca. Commun Med (Lond). 2024 May 16;4(1):87. doi: 10.1038/s43856-024-00505-y. Commun Med (Lond). 2024. PMID: 38755248 Free PMC article.
Survey of pharmaceutical industry's best practices around in vitro transporter assessment and Implications for Drug Development: Considerations from the IQ Transporter Working Group.
Rollison HE, Mitra P, Chanteux H, Fang Z, Liang X, Park SH, Costales C, Hanna I, Thakkar N, Vergis JM, Bow DAJ, Hillgren KM, Brumm J, Chu X, Hop CECA, Lai Y, Li CY, Mahar KM, Salphati L, Sane R, Shen H, Taskar K, Taub ME, Tohyama K, Xu C, Fenner KS. Rollison HE, et al. Among authors: hop ceca. Drug Metab Dispos. 2024 May 2:DMD-AR-2023-001587. doi: 10.1124/dmd.123.001587. Online ahead of print. Drug Metab Dispos. 2024. PMID: 38697852 Free article.
Artificial Intelligence for Quantitative Modeling in Drug Discovery and Development: An Innovation and Quality Consortium Perspective on Use Cases and Best Practices.
Terranova N, Renard D, Shahin MH, Menon S, Cao Y, Hop CECA, Hayes S, Madrasi K, Stodtmann S, Tensfeldt T, Vaddady P, Ellinwood N, Lu J. Terranova N, et al. Among authors: hop ceca. Clin Pharmacol Ther. 2024 Apr;115(4):658-672. doi: 10.1002/cpt.3053. Epub 2023 Oct 6. Clin Pharmacol Ther. 2024. PMID: 37716910 Review.
142 results