Bhat L - Search Results

1

Total synthesis of cryptophycin-24 (Arenastatin A) amenable to structural modifications in the C16 side chain.

Eggen M, Mossman CJ, Buck SB, Nair SK, Bhat L, Ali SM, Reiff EA, Boge TC, Georg GI. Eggen M, et al. Among authors: bhat l. J Org Chem. 2000 Nov 17;65(23):7792-9. doi: 10.1021/jo000767+. J Org Chem. 2000. PMID: 11073583

2

Synthesis and evaluation of paclitaxel C7 derivatives: solution phase synthesis of combinatorial libraries.

Bhat L, Liu Y, Victory SF, Himes RH, Georg GI. Bhat L, et al. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3181-6. doi: 10.1016/s0960-894x(98)00551-4. Bioorg Med Chem Lett. 1998. PMID: 9873699

3

Synthesis and biological evaluation of novel steroidal pyrazoles as substrates for bile acid transporters.

Bhat L, Jandeleit B, Dias TM, Moors TL, Gallop MA. Bhat L, et al. Bioorg Med Chem Lett. 2005 Jan 3;15(1):85-7. doi: 10.1016/j.bmcl.2004.10.027. Bioorg Med Chem Lett. 2005. PMID: 15582416

4

RP5063, a novel, multimodal, serotonin receptor modulator, prevents Sugen 5416-hypoxia-induced pulmonary arterial hypertension in rats.

Bhat L, Hawkinson J, Cantillon M, Reddy DG, Bhat SR, Laurent CE, Bouchard A, Biernat M, Salvail D. Bhat L, et al. Among authors: bhat sr. Eur J Pharmacol. 2017 Sep 5;810:83-91. doi: 10.1016/j.ejphar.2017.05.052. Epub 2017 May 31. Eur J Pharmacol. 2017. PMID: 28576407 Free article.

5

RP5063, a novel, multimodal, serotonin receptor modulator, prevents monocrotaline-induced pulmonary arterial hypertension in rats.

Bhat L, Hawkinson J, Cantillon M, Reddy DG, Bhat SR, Laurent CE, Bouchard A, Biernat M, Salvail D. Bhat L, et al. Among authors: bhat sr. Eur J Pharmacol. 2017 Sep 5;810:92-99. doi: 10.1016/j.ejphar.2017.05.048. Epub 2017 May 31. Eur J Pharmacol. 2017. PMID: 28577964 Free article.

6

Evaluation of the effects of RP5063, a novel, multimodal, serotonin receptor modulator, as single-agent therapy and co-administrated with sildenafil, bosentan, and treprostinil in a monocrotaline-induced pulmonary arterial hypertension rat model.

Bhat L, Hawkinson J, Cantillon M, Reddy DG, Bhat SR, Laurent CE, Bouchard A, Biernat M, Salvail D. Bhat L, et al. Among authors: bhat sr. Eur J Pharmacol. 2018 May 15;827:159-166. doi: 10.1016/j.ejphar.2018.02.017. Epub 2018 Feb 14. Eur J Pharmacol. 2018. PMID: 29453947 Free article.

7

Dopamine serotonin stabilizer RP5063: A randomized, double-blind, placebo-controlled multicenter trial of safety and efficacy in exacerbation of schizophrenia or schizoaffective disorder.

Cantillon M, Prakash A, Alexander A, Ings R, Sweitzer D, Bhat L. Cantillon M, et al. Among authors: bhat l. Schizophr Res. 2017 Nov;189:126-133. doi: 10.1016/j.schres.2017.01.043. Epub 2017 Feb 16. Schizophr Res. 2017. PMID: 28215471 Clinical Trial.

8

Pharmacokinetics of RP5063 Following Single Doses to Normal Healthy Volunteers and Multiple Doses Over 10 Days to Stable Schizophrenic Patients.

Cantillon M, Ings R, Bhat L. Cantillon M, et al. Among authors: bhat l. Clin Transl Sci. 2018 Jul;11(4):378-386. doi: 10.1111/cts.12518. Epub 2017 Nov 8. Clin Transl Sci. 2018. PMID: 29119704 Free PMC article. Clinical Trial.

9

Response to concerns over Cantillon et al. dopamine serotonin stabilizer RP5063 clinical trial's design, analyses and findings (SCHRES-D-17-00455) by Ahmed S Aboraya, MD, DrPh.

Cantillon M, Bhat L. Cantillon M, et al. Among authors: bhat l. Schizophr Res. 2018 May;195:581-582. doi: 10.1016/j.schres.2017.09.010. Epub 2018 Feb 1. Schizophr Res. 2018. PMID: 29395606 No abstract available.

10

A Population Pharmacokinetic and Pharmacodynamic Analysis of RP5063 Phase 2 Study Data in Patients with Schizophrenia or Schizoaffective Disorder.

Cantillon M, Ings R, Prakash A, Bhat L. Cantillon M, et al. Among authors: bhat l. Eur J Drug Metab Pharmacokinet. 2018 Oct;43(5):573-585. doi: 10.1007/s13318-018-0472-z. Eur J Drug Metab Pharmacokinet. 2018. PMID: 29619682 Free PMC article. Clinical Trial.

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