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Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.
McLaurin J, Cecal R, Kierstead ME, Tian X, Phinney AL, Manea M, French JE, Lambermon MH, Darabie AA, Brown ME, Janus C, Chishti MA, Horne P, Westaway D, Fraser PE, Mount HT, Przybylski M, St George-Hyslop P. McLaurin J, et al. Among authors: french je. Nat Med. 2002 Nov;8(11):1263-9. doi: 10.1038/nm790. Epub 2002 Oct 15. Nat Med. 2002. PMID: 12379850
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.
Chishti MA, Yang DS, Janus C, Phinney AL, Horne P, Pearson J, Strome R, Zuker N, Loukides J, French J, Turner S, Lozza G, Grilli M, Kunicki S, Morissette C, Paquette J, Gervais F, Bergeron C, Fraser PE, Carlson GA, George-Hyslop PS, Westaway D. Chishti MA, et al. Among authors: french j. J Biol Chem. 2001 Jun 15;276(24):21562-70. doi: 10.1074/jbc.M100710200. Epub 2001 Mar 15. J Biol Chem. 2001. PMID: 11279122 Free article.
Notably, learning impairment in young mice was offset by immunization against Abeta42 (Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., Mount, H. T. J., Nixon, R. …
Notably, learning impairment in young mice was offset by immunization against Abeta42 (Janus, C., Pearson, J., McLaurin, J., M …
UCHL1-dependent control of Hypoxia-Inducible Factor Transcriptional Activity during Liver Fibrosis.
Collins A, Scott R, Wilson CL, Abbate G, Ecclestone G, Albanese AG, Biddles D, White S, French J, Moir J, Alrawashdeh W, Wilson C, Pandanaboyana S, Hammond JS, Thakkar R, Oakley F, Mann J, Mann D, Kenneth N. Collins A, et al. Among authors: french j. Biosci Rep. 2024 May 29:BSR20232147. doi: 10.1042/BSR20232147. Online ahead of print. Biosci Rep. 2024. PMID: 38808772
Learning difficulties often not documented in newly diagnosed focal epilepsy.
Parekh P, Wheless H, Freglette C, French J, Morrison C, Pellinen J; Human Epilepsy Project Investigators. Parekh P, et al. Among authors: french j. Epilepsy Behav. 2024 May 16;156:109837. doi: 10.1016/j.yebeh.2024.109837. Online ahead of print. Epilepsy Behav. 2024. PMID: 38759428
Teratogenesis, Perinatal, and Neurodevelopmental Outcomes After In Utero Exposure to Antiseizure Medication: Practice Guideline From the AAN, AES, and SMFM.
Pack AM, Oskoui M, Williams Roberson S, Donley DK, French J, Gerard EE, Gloss D, Miller WR, Munger Clary HM, Osmundson SS, McFadden B, Parratt K, Pennell PB, Saade G, Smith DB, Sullivan K, Thomas SV, Tomson T, Dolan O'Brien M, Botchway-Doe K, Silsbee HM, Keezer MR. Pack AM, et al. Among authors: french j. Neurology. 2024 Jun;102(11):e209279. doi: 10.1212/WNL.0000000000209279. Epub 2024 May 15. Neurology. 2024. PMID: 38748979
2,394 results