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Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St George-Hyslop P, Carlson GA, Westaway D. Mastrangelo P, et al. Among authors: jiang y. Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8972-7. doi: 10.1073/pnas.0500940102. Epub 2005 Jun 10. Proc Natl Acad Sci U S A. 2005. PMID: 15951428 Free PMC article.
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.
Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson D, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA. Yang DS, et al. Among authors: jiang y. Brain. 2011 Jan;134(Pt 1):258-77. doi: 10.1093/brain/awq341. Brain. 2011. PMID: 21186265 Free PMC article.
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease.
Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, Jiang Y, Duff K, Uchiyama Y, Näslund J, Mathews PM, Cataldo AM, Nixon RA. Yu WH, et al. Among authors: jiang y. J Cell Biol. 2005 Oct 10;171(1):87-98. doi: 10.1083/jcb.200505082. Epub 2005 Oct 3. J Cell Biol. 2005. PMID: 16203860 Free PMC article.
Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis.
Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson DW, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA. Yang DS, et al. Among authors: jiang y. Autophagy. 2011 Jul;7(7):788-9. doi: 10.4161/auto.7.7.15596. Epub 2011 Jul 1. Autophagy. 2011. PMID: 21464620 Free PMC article.
Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis.
Mathews PM, Guerra CB, Jiang Y, Grbovic OM, Kao BH, Schmidt SD, Dinakar R, Mercken M, Hille-Rehfeld A, Rohrer J, Mehta P, Cataldo AM, Nixon RA. Mathews PM, et al. Among authors: jiang y. J Biol Chem. 2002 Feb 15;277(7):5299-307. doi: 10.1074/jbc.M108161200. Epub 2001 Sep 10. J Biol Chem. 2002. PMID: 11551970 Free article.
Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production.
Grbovic OM, Mathews PM, Jiang Y, Schmidt SD, Dinakar R, Summers-Terio NB, Ceresa BP, Nixon RA, Cataldo AM. Grbovic OM, et al. Among authors: jiang y. J Biol Chem. 2003 Aug 15;278(33):31261-8. doi: 10.1074/jbc.M304122200. Epub 2003 May 20. J Biol Chem. 2003. PMID: 12761223 Free article.
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