Mercken M - Search Results

1

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.

Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti MA, Horne P, Heslin D, French J, Mount HT, Nixon RA, Mercken M, Bergeron C, Fraser PE, St George-Hyslop P, Westaway D. Janus C, et al. Among authors: mercken m. Nature. 2000 Dec 21-28;408(6815):979-82. doi: 10.1038/35050110. Nature. 2000. PMID: 11140685

2

Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.

Rozmahel R, Huang J, Chen F, Liang Y, Nguyen V, Ikeda M, Levesque G, Yu G, Nishimura M, Mathews P, Schmidt SD, Mercken M, Bergeron C, Westaway D, St George-Hyslop P. Rozmahel R, et al. Among authors: mercken m. Neurobiol Aging. 2002 Mar-Apr;23(2):187-94. doi: 10.1016/s0197-4580(01)00267-6. Neurobiol Aging. 2002. PMID: 11804702

3

Extracellular amyloid formation and associated pathology in neural grafts.

Meyer-Luehmann M, Stalder M, Herzig MC, Kaeser SA, Kohler E, Pfeifer M, Boncristiano S, Mathews PM, Mercken M, Abramowski D, Staufenbiel M, Jucker M. Meyer-Luehmann M, et al. Among authors: mercken m. Nat Neurosci. 2003 Apr;6(4):370-7. doi: 10.1038/nn1022. Nat Neurosci. 2003. PMID: 12598899

4

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease.

Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, Jiang Y, Duff K, Uchiyama Y, Näslund J, Mathews PM, Cataldo AM, Nixon RA. Yu WH, et al. Among authors: mercken m. J Cell Biol. 2005 Oct 10;171(1):87-98. doi: 10.1083/jcb.200505082. Epub 2005 Oct 3. J Cell Biol. 2005. PMID: 16203860 Free PMC article.

5

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease.

Refolo LM, Pappolla MA, LaFrancois J, Malester B, Schmidt SD, Thomas-Bryant T, Tint GS, Wang R, Mercken M, Petanceska SS, Duff KE. Refolo LM, et al. Among authors: mercken m. Neurobiol Dis. 2001 Oct;8(5):890-9. doi: 10.1006/nbdi.2001.0422. Neurobiol Dis. 2001. PMID: 11592856

6

Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis.

Mathews PM, Guerra CB, Jiang Y, Grbovic OM, Kao BH, Schmidt SD, Dinakar R, Mercken M, Hille-Rehfeld A, Rohrer J, Mehta P, Cataldo AM, Nixon RA. Mathews PM, et al. Among authors: mercken m. J Biol Chem. 2002 Feb 15;277(7):5299-307. doi: 10.1074/jbc.M108161200. Epub 2001 Sep 10. J Biol Chem. 2002. PMID: 11551970 Free article.

7

Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments.

Mathews PM, Jiang Y, Schmidt SD, Grbovic OM, Mercken M, Nixon RA. Mathews PM, et al. Among authors: mercken m. J Biol Chem. 2002 Sep 27;277(39):36415-24. doi: 10.1074/jbc.M205208200. Epub 2002 Jun 26. J Biol Chem. 2002. PMID: 12087104 Free article.

8

Differential sensitivity to proteolysis by brain calpain of adult human tau, fetal human tau and PHF-tau.

Mercken M, Grynspan F, Nixon RA. Mercken M, et al. FEBS Lett. 1995 Jul 10;368(1):10-4. doi: 10.1016/0014-5793(95)00590-6. FEBS Lett. 1995. PMID: 7615058 Free article.

9

Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.

Burns M, Gaynor K, Olm V, Mercken M, LaFrancois J, Wang L, Mathews PM, Noble W, Matsuoka Y, Duff K. Burns M, et al. Among authors: mercken m. J Neurosci. 2003 Jul 2;23(13):5645-9. doi: 10.1523/JNEUROSCI.23-13-05645.2003. J Neurosci. 2003. PMID: 12843267 Free PMC article.

10

Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: evidence for dynamic interactions of tau with microtubules in vivo.

Mercken M, Fischer I, Kosik KS, Nixon RA. Mercken M, et al. J Neurosci. 1995 Dec;15(12):8259-67. doi: 10.1523/JNEUROSCI.15-12-08259.1995. J Neurosci. 1995. PMID: 8613759 Free PMC article.

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