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Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A.
Kuznetsov G, Xu Q, Rudolph-Owen L, Tendyke K, Liu J, Towle M, Zhao N, Marsh J, Agoulnik S, Twine N, Parent L, Chen Z, Shie JL, Jiang Y, Zhang H, Du H, Boivin R, Wang Y, Romo D, Littlefield BA. Kuznetsov G, et al. Mol Cancer Ther. 2009 May;8(5):1250-60. doi: 10.1158/1535-7163.MCT-08-1026. Epub 2009 May 5. Mol Cancer Ther. 2009. PMID: 19417157 Free PMC article.
Structurally simplified macrolactone analogues of halichondrin B.
Seletsky BM, Wang Y, Hawkins LD, Palme MH, Habgood GJ, DiPietro LV, Towle MJ, Salvato KA, Wels BF, Aalfs KK, Kishi Y, Littlefield BA, Yu MJ. Seletsky BM, et al. Among authors: towle mj. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5547-50. doi: 10.1016/j.bmcl.2004.08.068. Bioorg Med Chem Lett. 2004. PMID: 15482921
Macrocyclic ketone analogues of halichondrin B.
Zheng W, Seletsky BM, Palme MH, Lydon PJ, Singer LA, Chase CE, Lemelin CA, Shen Y, Davis H, Tremblay L, Towle MJ, Salvato KA, Wels BF, Aalfs KK, Kishi Y, Littlefield BA, Yu MJ. Zheng W, et al. Among authors: towle mj. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5551-4. doi: 10.1016/j.bmcl.2004.08.069. Bioorg Med Chem Lett. 2004. PMID: 15482922
Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin.
Kuznetsov G, TenDyke K, Towle MJ, Cheng H, Liu J, Marsh JP, Schiller SE, Spyvee MR, Yang H, Seletsky BM, Shaffer CJ, Marceau V, Yao Y, Suh EM, Campagna S, Fang FG, Kowalczyk JJ, Littlefield BA. Kuznetsov G, et al. Among authors: towle mj. Mol Cancer Ther. 2009 Oct;8(10):2852-60. doi: 10.1158/1535-7163.MCT-09-0301. Mol Cancer Ther. 2009. PMID: 19825803
Novel second generation analogs of eribulin. Part I: Compounds containing a lipophilic C32 side chain overcome P-glycoprotein susceptibility.
Narayan S, Carlson EM, Cheng H, Du H, Hu Y, Jiang Y, Lewis BM, Seletsky BM, Tendyke K, Zhang H, Zheng W, Littlefield BA, Towle MJ, Yu MJ. Narayan S, et al. Among authors: towle mj. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1630-3. doi: 10.1016/j.bmcl.2011.01.111. Epub 2011 Jan 31. Bioorg Med Chem Lett. 2011. PMID: 21324686
23 results