Jaakkola P - Search Results

1

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ. Jaakkola P, et al. Science. 2001 Apr 20;292(5516):468-72. doi: 10.1126/science.1059796. Epub 2001 Apr 5. Science. 2001. PMID: 11292861

2

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.

Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH. Cockman ME, et al. Among authors: jaakkola p. J Biol Chem. 2000 Aug 18;275(33):25733-41. doi: 10.1074/jbc.M002740200. J Biol Chem. 2000. PMID: 10823831 Free article.

3

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. Epstein AC, et al. Among authors: jaakkola p. Cell. 2001 Oct 5;107(1):43-54. doi: 10.1016/s0092-8674(01)00507-4. Cell. 2001. PMID: 11595184 Free article.

4

Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.

Marxsen JH, Stengel P, Doege K, Heikkinen P, Jokilehto T, Wagner T, Jelkmann W, Jaakkola P, Metzen E. Marxsen JH, et al. Among authors: jaakkola p. Biochem J. 2004 Aug 1;381(Pt 3):761-7. doi: 10.1042/BJ20040620. Biochem J. 2004. PMID: 15104534 Free PMC article.

5

The role of HIF prolyl hydroxylases in tumour growth.

Jokilehto T, Jaakkola PM. Jokilehto T, et al. J Cell Mol Med. 2010 Apr;14(4):758-70. doi: 10.1111/j.1582-4934.2010.01030.x. Epub 2010 Feb 22. J Cell Mol Med. 2010. PMID: 20178464 Free PMC article. Review.

6

The regulation, localization, and functions of oxygen-sensing prolyl hydroxylase PHD3.

Jaakkola PM, Rantanen K. Jaakkola PM, et al. Biol Chem. 2013 Apr;394(4):449-57. doi: 10.1515/hsz-2012-0330. Biol Chem. 2013. PMID: 23380539 Review.

7

Prolyl hydroxylase PHD3 activates oxygen-dependent protein aggregation.

Rantanen K, Pursiheimo J, Högel H, Himanen V, Metzen E, Jaakkola PM. Rantanen K, et al. Mol Biol Cell. 2008 May;19(5):2231-40. doi: 10.1091/mbc.e07-11-1124. Epub 2008 Mar 12. Mol Biol Cell. 2008. PMID: 18337469 Free PMC article.

8

Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62.

Pursiheimo JP, Rantanen K, Heikkinen PT, Johansen T, Jaakkola PM. Pursiheimo JP, et al. Among authors: jaakkola pm. Oncogene. 2009 Jan 22;28(3):334-44. doi: 10.1038/onc.2008.392. Epub 2008 Oct 20. Oncogene. 2009. PMID: 18931699

9

Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness.

Jokilehto T, Rantanen K, Luukkaa M, Heikkinen P, Grenman R, Minn H, Kronqvist P, Jaakkola PM. Jokilehto T, et al. Among authors: jaakkola pm. Clin Cancer Res. 2006 Feb 15;12(4):1080-7. doi: 10.1158/1078-0432.CCR-05-2022. Clin Cancer Res. 2006. PMID: 16489060

10

p62/SQSTM1 regulates cellular oxygen sensing by attenuating PHD3 activity through aggregate sequestration and enhanced degradation.

Rantanen K, Pursiheimo JP, Högel H, Miikkulainen P, Sundström J, Jaakkola PM. Rantanen K, et al. Among authors: jaakkola pm. J Cell Sci. 2013 Mar 1;126(Pt 5):1144-54. doi: 10.1242/jcs.115667. Epub 2013 Jan 23. J Cell Sci. 2013. PMID: 23345396

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