Maxwell PH - Search Results

1

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ. Jaakkola P, et al. Among authors: maxwell ph. Science. 2001 Apr 20;292(5516):468-72. doi: 10.1126/science.1059796. Epub 2001 Apr 5. Science. 2001. PMID: 11292861

2

Oxygen sensors and angiogenesis.

Maxwell PH, Ratcliffe PJ. Maxwell PH, et al. Semin Cell Dev Biol. 2002 Feb;13(1):29-37. doi: 10.1006/scdb.2001.0287. Semin Cell Dev Biol. 2002. PMID: 11969369 Review.

3

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.

Hon WC, Wilson MI, Harlos K, Claridge TD, Schofield CJ, Pugh CW, Maxwell PH, Ratcliffe PJ, Stuart DI, Jones EY. Hon WC, et al. Among authors: maxwell ph. Nature. 2002 Jun 27;417(6892):975-8. doi: 10.1038/nature00767. Epub 2002 Jun 5. Nature. 2002. PMID: 12050673

4

Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.

Mole DR, Pugh CW, Ratcliffe PJ, Maxwell PH. Mole DR, et al. Among authors: maxwell ph. Adv Enzyme Regul. 2002;42:333-47. doi: 10.1016/s0065-2571(01)00037-1. Adv Enzyme Regul. 2002. PMID: 12123724 No abstract available.

5

Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis.

Willam C, Masson N, Tian YM, Mahmood SA, Wilson MI, Bicknell R, Eckardt KU, Maxwell PH, Ratcliffe PJ, Pugh CW. Willam C, et al. Among authors: maxwell ph. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10423-8. doi: 10.1073/pnas.162119399. Epub 2002 Jul 29. Proc Natl Acad Sci U S A. 2002. PMID: 12149454 Free PMC article.

6

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, Li JL, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ. Raval RR, et al. Among authors: maxwell ph. Mol Cell Biol. 2005 Jul;25(13):5675-86. doi: 10.1128/MCB.25.13.5675-5686.2005. Mol Cell Biol. 2005. PMID: 15964822 Free PMC article.

7

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.

Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH. Cockman ME, et al. Among authors: maxwell ph. J Biol Chem. 2000 Aug 18;275(33):25733-41. doi: 10.1074/jbc.M002740200. J Biol Chem. 2000. PMID: 10823831 Free article.

8

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling.

Wykoff CC, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ. Wykoff CC, et al. Among authors: maxwell ph. Oncogene. 2000 Dec 14;19(54):6297-305. doi: 10.1038/sj.onc.1204012. Oncogene. 2000. PMID: 11175344

9

Activation of the HIF pathway in cancer.

Maxwell PH, Pugh CW, Ratcliffe PJ. Maxwell PH, et al. Curr Opin Genet Dev. 2001 Jun;11(3):293-9. doi: 10.1016/s0959-437x(00)00193-3. Curr Opin Genet Dev. 2001. PMID: 11377966 Review.

10

Insights into the role of the von Hippel-Lindau gene product. A key player in hypoxic regulation.

Maxwell PH, Pugh CW, Ratcliffe PJ. Maxwell PH, et al. Exp Nephrol. 2001;9(4):235-40. doi: 10.1159/000052617. Exp Nephrol. 2001. PMID: 11423722 Review.

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