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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.
Roberds SL, Anderson J, Basi G, Bienkowski MJ, Branstetter DG, Chen KS, Freedman SB, Frigon NL, Games D, Hu K, Johnson-Wood K, Kappenman KE, Kawabe TT, Kola I, Kuehn R, Lee M, Liu W, Motter R, Nichols NF, Power M, Robertson DW, Schenk D, Schoor M, Shopp GM, Shuck ME, Sinha S, Svensson KA, Tatsuno G, Tintrup H, Wijsman J, Wright S, McConlogue L. Roberds SL, et al. Among authors: basi g. Hum Mol Genet. 2001 Jun 1;10(12):1317-24. doi: 10.1093/hmg/10.12.1317. Hum Mol Genet. 2001. PMID: 11406613
Purification and cloning of amyloid precursor protein beta-secretase from human brain.
Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, Zhao J, McConlogue L, John V. Sinha S, et al. Among authors: basi gs. Nature. 1999 Dec 2;402(6761):537-40. doi: 10.1038/990114. Nature. 1999. PMID: 10591214
Treatment strategies targeting amyloid β-protein.
Schenk D, Basi GS, Pangalos MN. Schenk D, et al. Among authors: basi gs. Cold Spring Harb Perspect Med. 2012 Sep 1;2(9):a006387. doi: 10.1101/cshperspect.a006387. Cold Spring Harb Perspect Med. 2012. PMID: 22951439 Free PMC article. Review.
Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
Basi GS, Feinberg H, Oshidari F, Anderson J, Barbour R, Baker J, Comery TA, Diep L, Gill D, Johnson-Wood K, Goel A, Grantcharova K, Lee M, Li J, Partridge A, Griswold-Prenner I, Piot N, Walker D, Widom A, Pangalos MN, Seubert P, Jacobsen JS, Schenk D, Weis WI. Basi GS, et al. J Biol Chem. 2010 Jan 29;285(5):3417-27. doi: 10.1074/jbc.M109.045187. Epub 2009 Nov 18. J Biol Chem. 2010. PMID: 19923222 Free PMC article.
51 results