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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.
Roberds SL, Anderson J, Basi G, Bienkowski MJ, Branstetter DG, Chen KS, Freedman SB, Frigon NL, Games D, Hu K, Johnson-Wood K, Kappenman KE, Kawabe TT, Kola I, Kuehn R, Lee M, Liu W, Motter R, Nichols NF, Power M, Robertson DW, Schenk D, Schoor M, Shopp GM, Shuck ME, Sinha S, Svensson KA, Tatsuno G, Tintrup H, Wijsman J, Wright S, McConlogue L. Roberds SL, et al. Among authors: bienkowski mj. Hum Mol Genet. 2001 Jun 1;10(12):1317-24. doi: 10.1093/hmg/10.12.1317. Hum Mol Genet. 2001. PMID: 11406613
BACE2 functions as an alternative alpha-secretase in cells.
Yan R, Munzner JB, Shuck ME, Bienkowski MJ. Yan R, et al. Among authors: bienkowski mj. J Biol Chem. 2001 Sep 7;276(36):34019-27. doi: 10.1074/jbc.M105583200. Epub 2001 Jun 22. J Biol Chem. 2001. PMID: 11423558 Free article.
Human beta-secretase (BACE) and BACE inhibitors.
John V, Beck JP, Bienkowski MJ, Sinha S, Heinrikson RL. John V, et al. Among authors: bienkowski mj. J Med Chem. 2003 Oct 23;46(22):4625-30. doi: 10.1021/jm030247h. J Med Chem. 2003. PMID: 14561080 Review. No abstract available.
49 results