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8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists.
Gilligan PJ, He L, Clarke T, Tivitmahaisoon P, Lelas S, Li YW, Heman K, Fitzgerald L, Miller K, Zhang G, Marshall A, Krause C, McElroy J, Ward K, Shen H, Wong H, Grossman S, Nemeth G, Zaczek R, Arneric SP, Hartig P, Robertson DW, Trainor G. Gilligan PJ, et al. Among authors: robertson dw. J Med Chem. 2009 May 14;52(9):3073-83. doi: 10.1021/jm9000242. J Med Chem. 2009. PMID: 19361210
Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors.
Thompson LA, Liauw AY, Ramanjulu MM, Kasireddy-Polam P, Mercer SE, Maduskuie TP, Glicksman M, Roach AH, Meredith JE, Liu RQ, Combs AP, Higaki JN, Cordell B, Seiffert D, Zaczek RC, Robertson DW, Olson RE. Thompson LA, et al. Among authors: robertson dw. Bioorg Med Chem Lett. 2006 May 1;16(9):2357-63. doi: 10.1016/j.bmcl.2006.01.055. Epub 2006 Feb 10. Bioorg Med Chem Lett. 2006. PMID: 16473009
Aza-retinoids as novel retinoid X receptor-specific agonists.
Farmer LJ, Marron KS, Canan Koch SS, Hwang CK, Kallel EA, Zhi L, Nadzan AM, Robertson DW, Bennani YL. Farmer LJ, et al. Among authors: robertson dw. Bioorg Med Chem Lett. 2006 May 1;16(9):2352-6. doi: 10.1016/j.bmcl.2005.12.003. Epub 2005 Dec 20. Bioorg Med Chem Lett. 2006. PMID: 16364638
Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 receptors in rats.
Lelas S, Wong H, Li YW, Heman KL, Ward KA, Zeller KL, Sieracki KK, Polino JL, Godonis HE, Ren SX, Yan XX, Arneric SP, Robertson DW, Hartig PR, Grossman S, Trainor GL, Taub RA, Zaczek R, Gilligan PJ, McElroy JF. Lelas S, et al. Among authors: robertson dw. J Pharmacol Exp Ther. 2004 Apr;309(1):293-302. doi: 10.1124/jpet.103.058784. Epub 2004 Jan 23. J Pharmacol Exp Ther. 2004. PMID: 14742750
124 results