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CTLA-4 expressed by chemoresistant, as well as untreated, myeloid leukaemia cells can be targeted with ligands to induce apoptosis.
Laurent S, Palmisano GL, Martelli AM, Kato T, Tazzari PL, Pierri I, Clavio M, Dozin B, Balbi G, Megna M, Morabito A, Lamparelli T, Bacigalupo A, Gobbi M, Pistillo MP. Laurent S, et al. Among authors: palmisano gl. Br J Haematol. 2007 Feb;136(4):597-608. doi: 10.1111/j.1365-2141.2006.06472.x. Br J Haematol. 2007. PMID: 17367412 Free article.
CTLA-4 is not restricted to the lymphoid cell lineage and can function as a target molecule for apoptosis induction of leukemic cells.
Pistillo MP, Tazzari PL, Palmisano GL, Pierri I, Bolognesi A, Ferlito F, Capanni P, Polito L, Ratta M, Pileri S, Piccioli M, Basso G, Rissotto L, Conte R, Gobbi M, Stirpe F, Ferrara GB. Pistillo MP, et al. Among authors: palmisano gl. Blood. 2003 Jan 1;101(1):202-9. doi: 10.1182/blood-2002-06-1668. Epub 2002 Aug 15. Blood. 2003. PMID: 12393538 Free article.
CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction.
Contardi E, Palmisano GL, Tazzari PL, Martelli AM, Falà F, Fabbi M, Kato T, Lucarelli E, Donati D, Polito L, Bolognesi A, Ricci F, Salvi S, Gargaglione V, Mantero S, Alberghini M, Ferrara GB, Pistillo MP. Contardi E, et al. Among authors: palmisano gl. Int J Cancer. 2005 Nov 20;117(4):538-50. doi: 10.1002/ijc.21155. Int J Cancer. 2005. PMID: 15912538 Free article.
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