Kegel KB - Search Results

1

Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription.

Kegel KB, Meloni AR, Yi Y, Kim YJ, Doyle E, Cuiffo BG, Sapp E, Wang Y, Qin ZH, Chen JD, Nevins JR, Aronin N, DiFiglia M. Kegel KB, et al. J Biol Chem. 2002 Mar 1;277(9):7466-76. doi: 10.1074/jbc.M103946200. Epub 2001 Dec 5. J Biol Chem. 2002. PMID: 11739372 Free article.

2

Autophagy regulates the processing of amino terminal huntingtin fragments.

Qin ZH, Wang Y, Kegel KB, Kazantsev A, Apostol BL, Thompson LM, Yoder J, Aronin N, DiFiglia M. Qin ZH, et al. Among authors: kegel kb. Hum Mol Genet. 2003 Dec 15;12(24):3231-44. doi: 10.1093/hmg/ddg346. Epub 2003 Oct 21. Hum Mol Genet. 2003. PMID: 14570716

3

Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.

Qin ZH, Wang Y, Sapp E, Cuiffo B, Wanker E, Hayden MR, Kegel KB, Aronin N, DiFiglia M. Qin ZH, et al. Among authors: kegel kb. J Neurosci. 2004 Jan 7;24(1):269-81. doi: 10.1523/JNEUROSCI.1409-03.2004. J Neurosci. 2004. PMID: 14715959 Free PMC article.

4

Huntingtin associates with acidic phospholipids at the plasma membrane.

Kegel KB, Sapp E, Yoder J, Cuiffo B, Sobin L, Kim YJ, Qin ZH, Hayden MR, Aronin N, Scott DL, Isenberg G, Goldmann WH, DiFiglia M. Kegel KB, et al. J Biol Chem. 2005 Oct 28;280(43):36464-73. doi: 10.1074/jbc.M503672200. Epub 2005 Aug 5. J Biol Chem. 2005. PMID: 16085648 Free article.

5

Lysosomal proteases are involved in generation of N-terminal huntingtin fragments.

Kim YJ, Sapp E, Cuiffo BG, Sobin L, Yoder J, Kegel KB, Qin ZH, Detloff P, Aronin N, DiFiglia M. Kim YJ, et al. Among authors: kegel kb. Neurobiol Dis. 2006 May;22(2):346-56. doi: 10.1016/j.nbd.2005.11.012. Epub 2006 Jan 19. Neurobiol Dis. 2006. PMID: 16423528

6

Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer.

Sapp E, Valencia A, Li X, Aronin N, Kegel KB, Vonsattel JP, Young AB, Wexler N, DiFiglia M. Sapp E, et al. Among authors: kegel kb. J Biol Chem. 2012 Apr 13;287(16):13487-99. doi: 10.1074/jbc.M111.286609. Epub 2012 Feb 27. J Biol Chem. 2012. PMID: 22375012 Free PMC article.

7

Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.

Kegel KB, Kim M, Sapp E, McIntyre C, Castaño JG, Aronin N, DiFiglia M. Kegel KB, et al. J Neurosci. 2000 Oct 1;20(19):7268-78. doi: 10.1523/JNEUROSCI.20-19-07268.2000. J Neurosci. 2000. PMID: 11007884 Free PMC article.

8

Pro-caspase-8 is predominantly localized in mitochondria and released into cytoplasm upon apoptotic stimulation.

Qin ZH, Wang Y, Kikly KK, Sapp E, Kegel KB, Aronin N, DiFiglia M. Qin ZH, et al. Among authors: kegel kb. J Biol Chem. 2001 Mar 16;276(11):8079-86. doi: 10.1074/jbc.M007028200. Epub 2000 Dec 1. J Biol Chem. 2001. PMID: 11102441 Free article.

9

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

Kim YJ, Yi Y, Sapp E, Wang Y, Cuiffo B, Kegel KB, Qin ZH, Aronin N, DiFiglia M. Kim YJ, et al. Among authors: kegel kb. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12784-9. doi: 10.1073/pnas.221451398. Proc Natl Acad Sci U S A. 2001. PMID: 11675509 Free PMC article.

10

A function of huntingtin in guanine nucleotide exchange on Rab11.

Li X, Sapp E, Valencia A, Kegel KB, Qin ZH, Alexander J, Masso N, Reeves P, Ritch JJ, Zeitlin S, Aronin N, Difiglia M. Li X, et al. Among authors: kegel kb. Neuroreport. 2008 Oct 29;19(16):1643-7. doi: 10.1097/WNR.0b013e328315cd4c. Neuroreport. 2008. PMID: 18845944

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