Jackman A - Search Results

1

Phase I and pharmacologic study of oral ZD9331, a novel nonpolyglutamated thymidylate synthase inhibitor, in adult patients with solid tumors.

de Jonge MJ, Punt CJ, Sparreboom A, Planting AS, Peters ME, van De Schraaf J, Jackman A, Smith R, de Mulder PH, Verweij J. de Jonge MJ, et al. Among authors: jackman a. J Clin Oncol. 2002 Apr 1;20(7):1923-31. doi: 10.1200/JCO.2002.07.057. J Clin Oncol. 2002. PMID: 11919253 Clinical Trial.

2

Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors.

Clarke SJ, Hanwell J, de Boer M, Planting A, Verweij J, Walker M, Smith R, Jackman AL, Hughes LR, Harrap KR, Kennealey GT, Judson IR. Clarke SJ, et al. Among authors: jackman al. J Clin Oncol. 1996 May;14(5):1495-503. doi: 10.1200/JCO.1996.14.5.1495. J Clin Oncol. 1996. PMID: 8622063 Clinical Trial.

3

Phase I trial of ZD9331, a nonpolyglutamatable thymidylate synthase inhibitor, given as a 5-day continuous infusion to patients with refractory solid malignancies.

Rees C, Beale P, Trigo JM, Mitchell F, Jackman A, Smith R, Douglass E, Judson I. Rees C, et al. Among authors: jackman a. Clin Cancer Res. 2003 Jun;9(6):2049-55. Clin Cancer Res. 2003. PMID: 12796367 Clinical Trial.

4

A phase I trial of ZD9331, a water-soluble, nonpolyglutamatable, thymidylate synthase inhibitor.

Plummer R, Rees C, Hughes A, Beale P, Highley M, Trigo J, Gokul S, Judson I, Calvert H, Jackman A, Mitchell F, Smith R, Douglass E. Plummer R, et al. Among authors: jackman a. Clin Cancer Res. 2003 Apr;9(4):1313-22. Clin Cancer Res. 2003. PMID: 12684399 Clinical Trial.

5

Patterns of elevation of plasma 2'-deoxyuridine, a surrogate marker of thymidylate synthase (TS) inhibition, after administration of two different schedules of 5-fluorouracil and the specific TS inhibitors raltitrexed (Tomudex) and ZD9331.

Ford HE, Mitchell F, Cunningham D, Farrugia DC, Hill ME, Rees C, Calvert AH, Judson IR, Jackman AL. Ford HE, et al. Among authors: jackman al. Clin Cancer Res. 2002 Jan;8(1):103-9. Clin Cancer Res. 2002. PMID: 11801545 Clinical Trial.

6

A phase I evaluation of the quinazoline antifolate thymidylate synthase inhibitor, N10-propargyl-5,8-dideazafolic acid, CB3717.

Calvert AH, Alison DL, Harland SJ, Robinson BA, Jackman AL, Jones TR, Newell DR, Siddik ZH, Wiltshaw E, McElwain TJ, et al. Calvert AH, et al. Among authors: jackman al. J Clin Oncol. 1986 Aug;4(8):1245-52. doi: 10.1200/JCO.1986.4.8.1245. J Clin Oncol. 1986. PMID: 3734849

7

Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase.

Jackman AL, Kimbell R, Aherne GW, Brunton L, Jansen G, Stephens TC, Smith MN, Wardleworth JM, Boyle FT. Jackman AL, et al. Clin Cancer Res. 1997 Jun;3(6):911-21. Clin Cancer Res. 1997. PMID: 9815766

8

The renal effects of the water-soluble, non-folylpolyglutamate synthetase-dependent thymidylate synthase inhibitor ZD9331 in mice.

Walton MI, Mitchell F, Aherne GW, Medlow CJ, Boyle FT, Jackman AL. Walton MI, et al. Among authors: jackman al. Br J Cancer. 1998 Dec;78(11):1457-63. doi: 10.1038/bjc.1998.707. Br J Cancer. 1998. PMID: 9836478 Free PMC article.

9

Pharmacokinetic/pharmacodynamic study of ZD9331, a nonpolyglutamatable inhibitor of thymidylate synthase, in a murine model following two curative administration schedules.

Aherne GW, Hardcastle A, Ward E, Dobinson D, Crompton T, Valenti M, Brunton L, Jackman AL. Aherne GW, et al. Among authors: jackman al. Clin Cancer Res. 2001 Sep;7(9):2923-30. Clin Cancer Res. 2001. PMID: 11555611

10

Folate-based thymidylate synthase inhibitors as anticancer drugs.

Jackman AL, Calvert AH. Jackman AL, et al. Ann Oncol. 1995 Nov;6(9):871-81. doi: 10.1093/oxfordjournals.annonc.a059353. Ann Oncol. 1995. PMID: 8624289 Free article. Review.

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