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Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis.
Pepys MB, Herbert J, Hutchinson WL, Tennent GA, Lachmann HJ, Gallimore JR, Lovat LB, Bartfai T, Alanine A, Hertel C, Hoffmann T, Jakob-Roetne R, Norcross RD, Kemp JA, Yamamura K, Suzuki M, Taylor GW, Murray S, Thompson D, Purvis A, Kolstoe S, Wood SP, Hawkins PN. Pepys MB, et al. Among authors: tennent ga. Nature. 2002 May 16;417(6886):254-9. doi: 10.1038/417254a. Nature. 2002. PMID: 12015594
Targeting C-reactive protein for the treatment of cardiovascular disease.
Pepys MB, Hirschfield GM, Tennent GA, Gallimore JR, Kahan MC, Bellotti V, Hawkins PN, Myers RM, Smith MD, Polara A, Cobb AJ, Ley SV, Aquilina JA, Robinson CV, Sharif I, Gray GA, Sabin CA, Jenvey MC, Kolstoe SE, Thompson D, Wood SP. Pepys MB, et al. Among authors: tennent ga. Nature. 2006 Apr 27;440(7088):1217-21. doi: 10.1038/nature04672. Nature. 2006. PMID: 16642000
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits.
Bodin K, Ellmerich S, Kahan MC, Tennent GA, Loesch A, Gilbertson JA, Hutchinson WL, Mangione PP, Gallimore JR, Millar DJ, Minogue S, Dhillon AP, Taylor GW, Bradwell AR, Petrie A, Gillmore JD, Bellotti V, Botto M, Hawkins PN, Pepys MB. Bodin K, et al. Among authors: tennent ga. Nature. 2010 Nov 4;468(7320):93-7. doi: 10.1038/nature09494. Epub 2010 Oct 20. Nature. 2010. PMID: 20962779 Free PMC article.
Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C-reactive protein, for clinical use.
Pepys MB, Gallimore JR, Lloyd J, Li Z, Graham D, Taylor GW, Ellmerich S, Mangione PP, Tennent GA, Hutchinson WL, Millar DJ, Bennett G, More J, Evans D, Mistry Y, Poole S, Hawkins PN. Pepys MB, et al. Among authors: tennent ga. J Immunol Methods. 2012 Oct 31;384(1-2):92-102. doi: 10.1016/j.jim.2012.07.013. Epub 2012 Jul 31. J Immunol Methods. 2012. PMID: 22867744 Free PMC article.
Human lysozyme gene mutations cause hereditary systemic amyloidosis.
Pepys MB, Hawkins PN, Booth DR, Vigushin DM, Tennent GA, Soutar AK, Totty N, Nguyen O, Blake CC, Terry CJ, et al. Pepys MB, et al. Among authors: tennent ga. Nature. 1993 Apr 8;362(6420):553-7. doi: 10.1038/362553a0. Nature. 1993. PMID: 8464497
64 results