White KL - Search Results

1

Molecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R+M184V and their effects on enzyme function and viral replication capacity.

White KL, Margot NA, Wrin T, Petropoulos CJ, Miller MD, Naeger LK. White KL, et al. Antimicrob Agents Chemother. 2002 Nov;46(11):3437-46. doi: 10.1128/AAC.46.11.3437-3446.2002. Antimicrob Agents Chemother. 2002. PMID: 12384348 Free PMC article.

2

Analysis of early resistance development at the first failure timepoint in elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate-treated patients.

White K, Kulkarni R, Miller MD. White K, et al. J Antimicrob Chemother. 2015 Sep;70(9):2632-8. doi: 10.1093/jac/dkv149. Epub 2015 Jun 24. J Antimicrob Chemother. 2015. PMID: 26108607 Clinical Trial.

3

Commonly Transmitted HIV-1 Drug Resistance Mutations in Reverse-Transcriptase and Protease in Antiretroviral Treatment-Naive Patients and Response to Regimens Containing Tenofovir Disoproxil Fumarate or Tenofovir Alafenamide.

Margot NA, Wong P, Kulkarni R, White K, Porter D, Abram ME, Callebaut C, Miller MD. Margot NA, et al. J Infect Dis. 2017 Mar 15;215(6):920-927. doi: 10.1093/infdis/jix015. J Infect Dis. 2017. PMID: 28453836

4

Molecular mechanisms of tenofovir resistance conferred by human immunodeficiency virus type 1 reverse transcriptase containing a diserine insertion after residue 69 and multiple thymidine analog-associated mutations.

White KL, Chen JM, Margot NA, Wrin T, Petropoulos CJ, Naeger LK, Swaminathan S, Miller MD. White KL, et al. Antimicrob Agents Chemother. 2004 Mar;48(3):992-1003. doi: 10.1128/AAC.48.3.992-1003.2004. Antimicrob Agents Chemother. 2004. PMID: 14982794 Free PMC article.

5

A combination of decreased NRTI incorporation and decreased excision determines the resistance profile of HIV-1 K65R RT.

White KL, Margot NA, Ly JK, Chen JM, Ray AS, Pavelko M, Wang R, McDermott M, Swaminathan S, Miller MD. White KL, et al. AIDS. 2005 Nov 4;19(16):1751-60. doi: 10.1097/01.aids.0000189851.21441.f1. AIDS. 2005. PMID: 16227782

6

The K65R reverse transcriptase mutation in HIV-1 reverses the excision phenotype of zidovudine resistance mutations.

White KL, Chen JM, Feng JY, Margot NA, Ly JK, Ray AS, Macarthur HL, McDermott MJ, Swaminathan S, Miller MD. White KL, et al. Antivir Ther. 2006;11(2):155-63. doi: 10.1177/135965350601100209. Antivir Ther. 2006. PMID: 16640096

7

Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir.

Marchand B, White KL, Ly JK, Margot NA, Wang R, McDermott M, Miller MD, Götte M. Marchand B, et al. Among authors: white kl. Antimicrob Agents Chemother. 2007 Aug;51(8):2911-9. doi: 10.1128/AAC.00314-07. Epub 2007 May 21. Antimicrob Agents Chemother. 2007. PMID: 17517852 Free PMC article.

8

The balance between NRTI discrimination and excision drives the susceptibility of HIV-1 RT mutants K65R, M184V and K65r+M184V.

Ly JK, Margot NA, MacArthur HL, Hung M, Miller MD, White KL. Ly JK, et al. Among authors: white kl. Antivir Chem Chemother. 2007;18(6):307-16. doi: 10.1177/095632020701800603. Antivir Chem Chemother. 2007. PMID: 18320935 Free article.

9

The A62V and S68G mutations in HIV-1 reverse transcriptase partially restore the replication defect associated with the K65R mutation.

Svarovskaia ES, Feng JY, Margot NA, Myrick F, Goodman D, Ly JK, White KL, Kutty N, Wang R, Borroto-Esoda K, Miller MD. Svarovskaia ES, et al. Among authors: white kl. J Acquir Immune Defic Syndr. 2008 Aug 1;48(4):428-36. doi: 10.1097/QAI.0b013e31817bbe93. J Acquir Immune Defic Syndr. 2008. PMID: 18614922

10

Impact of primary elvitegravir resistance-associated mutations in HIV-1 integrase on drug susceptibility and viral replication fitness.

Abram ME, Hluhanich RM, Goodman DD, Andreatta KN, Margot NA, Ye L, Niedziela-Majka A, Barnes TL, Novikov N, Chen X, Svarovskaia ES, McColl DJ, White KL, Miller MD. Abram ME, et al. Among authors: white kl. Antimicrob Agents Chemother. 2013 Jun;57(6):2654-63. doi: 10.1128/AAC.02568-12. Epub 2013 Mar 25. Antimicrob Agents Chemother. 2013. PMID: 23529738 Free PMC article.

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