A residue in the S2 subsite controls substrate selectivity of matrix metalloproteinase-2 and matrix metalloproteinase-9.
Chen EI, Li W, Godzik A, Howard EW, Smith JW.
Chen EI, et al. Among authors: li w.
J Biol Chem. 2003 May 9;278(19):17158-63. doi: 10.1074/jbc.M210324200. Epub 2003 Feb 18.
J Biol Chem. 2003.
PMID: 12591933
Free article.
Although the two MMPs exhibit some overlap in substrate recognition, our recent work showed that MMP-2 can cleave a set of peptide substrates that are only poorly recognized by MMP-9 (Chen, E. I., Kridel, S. J., Howard, E. W., Li, W., Godzik, A., and Smith, J …
Although the two MMPs exhibit some overlap in substrate recognition, our recent work showed that MMP-2 can cleave a set of peptide substrate …