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Single nucleotide polymorphisms modify the transporter activity of ABCG2.
Morisaki K, Robey RW, Ozvegy-Laczka C, Honjo Y, Polgar O, Steadman K, Sarkadi B, Bates SE. Morisaki K, et al. Among authors: bates se. Cancer Chemother Pharmacol. 2005 Aug;56(2):161-72. doi: 10.1007/s00280-004-0931-x. Epub 2005 Apr 19. Cancer Chemother Pharmacol. 2005. PMID: 15838659
Arginine 383 is a crucial residue in ABCG2 biogenesis.
Polgar O, Ediriwickrema LS, Robey RW, Sharma A, Hegde RS, Li Y, Xia D, Ward Y, Dean M, Ozvegy-Laczka C, Sarkadi B, Bates SE. Polgar O, et al. Among authors: bates se. Biochim Biophys Acta. 2009 Jul;1788(7):1434-43. doi: 10.1016/j.bbamem.2009.04.016. Epub 2009 May 3. Biochim Biophys Acta. 2009. PMID: 19406100 Free PMC article.
407 results