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Discovery of a novel series of indolinylpyrimidine-based GPR119 agonists: Elimination of ether-a-go-go-related gene liability using a hydrogen bond acceptor-focused approach.
Kamaura M, Kubo O, Sugimoto H, Noguchi N, Miyashita H, Abe S, Matsuda K, Tsujihata Y, Odani T, Iwasaki S, Murata T, Sato K. Kamaura M, et al. Among authors: kubo o. Bioorg Med Chem. 2021 Mar 15;34:116034. doi: 10.1016/j.bmc.2021.116034. Epub 2021 Jan 23. Bioorg Med Chem. 2021. PMID: 33548803 Free article.
Primary Intracranial Malignant Melanoma with Extracranial Metastasis.
Hirota K, Yoshimura C, Kubo O, Kasuya H. Hirota K, et al. Among authors: kubo o. J Korean Neurosurg Soc. 2017 Jan 1;60(1):98-101. doi: 10.3340/jkns.2015.0506.007. Epub 2016 Dec 29. J Korean Neurosurg Soc. 2017. PMID: 28061499 Free PMC article.
Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA:monoacylglycerol acyltransferase-2 inhibitors: Mitigation of CYP3A4 time-dependent inhibition and phototoxic liabilities.
Sato K, Takahagi H, Kubo O, Hidaka K, Yoshikawa T, Kamaura M, Nakakariya M, Amano N, Adachi R, Maki T, Take K, Takekawa S, Kitazaki T, Maekawa T. Sato K, et al. Among authors: kubo o. Bioorg Med Chem. 2015 Aug 1;23(15):4544-4560. doi: 10.1016/j.bmc.2015.06.003. Epub 2015 Jun 9. Bioorg Med Chem. 2015. PMID: 26100443
Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol Acyltransferase-2 Inhibitors.
Sato K, Takahagi H, Yoshikawa T, Morimoto S, Takai T, Hidaka K, Kamaura M, Kubo O, Adachi R, Ishii T, Maki T, Mochida T, Takekawa S, Nakakariya M, Amano N, Kitazaki T. Sato K, et al. Among authors: kubo o. J Med Chem. 2015 May 14;58(9):3892-909. doi: 10.1021/acs.jmedchem.5b00178. Epub 2015 Apr 30. J Med Chem. 2015. PMID: 25897973
239 results