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Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody.
Smethurst PA, Joutsi-Korhonen L, O'Connor MN, Wilson E, Jennings NS, Garner SF, Zhang Y, Knight CG, Dafforn TR, Buckle A, IJsseldijk MJ, De Groot PG, Watkins NA, Farndale RW, Ouwehand WH. Smethurst PA, et al. Blood. 2004 Feb 1;103(3):903-11. doi: 10.1182/blood-2003-01-0308. Epub 2003 Sep 22. Blood. 2004. PMID: 14504096 Free article.
The low-frequency allele of the platelet collagen signaling receptor glycoprotein VI is associated with reduced functional responses and expression.
Joutsi-Korhonen L, Smethurst PA, Rankin A, Gray E, IJsseldijk M, Onley CM, Watkins NA, Williamson LM, Goodall AH, de Groot PG, Farndale RW, Ouwehand WH. Joutsi-Korhonen L, et al. Among authors: smethurst pa. Blood. 2003 Jun 1;101(11):4372-9. doi: 10.1182/blood-2002-08-2591. Epub 2003 Jan 30. Blood. 2003. PMID: 12560230 Free article.
Selective blockade of glycoprotein VI clustering on collagen helices.
O'Connor MN, Smethurst PA, Davies LW, Joutsi-Korhonen L, Onley DJ, Herr AB, Farndale RW, Ouwehand WH. O'Connor MN, et al. Among authors: smethurst pa. J Biol Chem. 2006 Nov 3;281(44):33505-10. doi: 10.1074/jbc.M606480200. Epub 2006 Sep 6. J Biol Chem. 2006. PMID: 16956881 Free article.
Production of calmodulin-tagged proteins in Drosophila Schneider S2 cells: a novel system for antigen production and phage antibody isolation.
Jennings NS, Smethurst PA, Knight CG, O'Connor MN, Joutsi-Korhonen L, Stafford P, Stephens J, Garner SF, Harmer IJ, Farndale RW, Watkins NA, Ouwehand WH. Jennings NS, et al. Among authors: smethurst pa. J Immunol Methods. 2006 Oct 20;316(1-2):75-83. doi: 10.1016/j.jim.2006.08.003. Epub 2006 Sep 7. J Immunol Methods. 2006. PMID: 17027020
Identification of a major GpVI-binding locus in human type III collagen.
Jarvis GE, Raynal N, Langford JP, Onley DJ, Andrews A, Smethurst PA, Farndale RW. Jarvis GE, et al. Among authors: smethurst pa. Blood. 2008 May 15;111(10):4986-96. doi: 10.1182/blood-2007-08-108472. Epub 2008 Feb 27. Blood. 2008. PMID: 18305222 Free PMC article.
47 results