Leurs R - Search Results

1

Furin is a chemokine-modifying enzyme: in vitro and in vivo processing of CXCL10 generates a C-terminally truncated chemokine retaining full activity.

Hensbergen PJ, Verzijl D, Balog CI, Dijkman R, van der Schors RC, van der Raaij-Helmer EM, van der Plas MJ, Leurs R, Deelder AM, Smit MJ, Tensen CP. Hensbergen PJ, et al. Among authors: leurs r. J Biol Chem. 2004 Apr 2;279(14):13402-11. doi: 10.1074/jbc.M312814200. Epub 2004 Jan 21. J Biol Chem. 2004. PMID: 14739277 Free article.

2

Homologous histamine H1 receptor desensitization results in reduction of H1 receptor agonist efficacy.

Leurs R, Smit MJ, Bast A, Timmerman H. Leurs R, et al. Eur J Pharmacol. 1991 Apr 24;196(3):319-22. doi: 10.1016/0014-2999(91)90446-w. Eur J Pharmacol. 1991. PMID: 1654256

3

Molecular pharmacological aspects of histamine receptors.

Leurs R, Smit MJ, Timmerman H. Leurs R, et al. Pharmacol Ther. 1995 Jun;66(3):413-63. doi: 10.1016/0163-7258(95)00006-3. Pharmacol Ther. 1995. PMID: 7494855 Review.

4

Visualization of agonist-induced internalization of histamine H2 receptors.

Smit MJ, Timmerman H, Alewijnse AE, Punin M, van den Nieuwenhof I, Blauw J, van Minnen J, Leurs R. Smit MJ, et al. Among authors: leurs r. Biochem Biophys Res Commun. 1995 Sep 25;214(3):1138-45. doi: 10.1006/bbrc.1995.2404. Biochem Biophys Res Commun. 1995. PMID: 7575521

5

Lysine200 located in the fifth transmembrane domain of the histamine H1 receptor interacts with histamine but not with all H1 agonists.

Leurs R, Smit MJ, Meeder R, Ter Laak AM, Timmerman H. Leurs R, et al. Biochem Biophys Res Commun. 1995 Sep 5;214(1):110-7. doi: 10.1006/bbrc.1995.2263. Biochem Biophys Res Commun. 1995. PMID: 7669031

6

Rapid desensitization of the histamine H2 receptor on the human monocytic cell line U937.

Smit MJ, Leurs R, Shukrula SR, Bast A, Timmerman H. Smit MJ, et al. Among authors: leurs r. Eur J Pharmacol. 1994 Dec 15;288(1):17-25. doi: 10.1016/0922-4106(94)90005-1. Eur J Pharmacol. 1994. PMID: 7705464

7

Pharmacological characterization of the human histamine H2 receptor stably expressed in Chinese hamster ovary cells.

Leurs R, Smit MJ, Menge WM, Timmerman H. Leurs R, et al. Br J Pharmacol. 1994 Jul;112(3):847-54. doi: 10.1111/j.1476-5381.1994.tb13157.x. Br J Pharmacol. 1994. PMID: 7921611 Free PMC article.

8

Site-directed mutagenesis of the histamine H1-receptor reveals a selective interaction of asparagine207 with subclasses of H1-receptor agonists.

Leurs R, Smit MJ, Tensen CP, Ter Laak AM, Timmerman H. Leurs R, et al. Biochem Biophys Res Commun. 1994 May 30;201(1):295-301. doi: 10.1006/bbrc.1994.1701. Biochem Biophys Res Commun. 1994. PMID: 8198587

9

Extracellular ATP elevates cytoplasmatic free Ca2+ in HeLa cells by the interaction with a 5'-nucleotide receptor.

Smit MJ, Leurs R, Bloemers SM, Tertoolen LG, Bast A, De Laat SW, Timmerman H. Smit MJ, et al. Among authors: leurs r. Eur J Pharmacol. 1993 Oct 15;247(2):223-6. doi: 10.1016/0922-4106(93)90082-k. Eur J Pharmacol. 1993. PMID: 8282011

10

Modelling and mutation studies on the histamine H1-receptor agonist binding site reveal different binding modes for H1-agonists: Asp116 (TM3) has a constitutive role in receptor stimulation.

ter Laak AM, Timmerman H, Leurs R, Nederkoorn PH, Smit MJ, Donné-Op den Kelder GM. ter Laak AM, et al. Among authors: leurs r. J Comput Aided Mol Des. 1995 Aug;9(4):319-30. doi: 10.1007/BF00125173. J Comput Aided Mol Des. 1995. PMID: 8523041

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