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Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants.
Wu H, Shekar SC, Flinn RJ, El-Sibai M, Jaiswal BS, Sen KI, Janakiraman V, Seshagiri S, Gerfen GJ, Girvin ME, Backer JM. Wu H, et al. Among authors: jaiswal bs. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20258-63. doi: 10.1073/pnas.0902369106. Epub 2009 Nov 13. Proc Natl Acad Sci U S A. 2009. PMID: 19915146 Free PMC article.
Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation.
Jaiswal BS, Janakiraman V, Kljavin NM, Chaudhuri S, Stern HM, Wang W, Kan Z, Dbouk HA, Peters BA, Waring P, Dela Vega T, Kenski DM, Bowman KK, Lorenzo M, Li H, Wu J, Modrusan Z, Stinson J, Eby M, Yue P, Kaminker JS, de Sauvage FJ, Backer JM, Seshagiri S. Jaiswal BS, et al. Cancer Cell. 2009 Dec 8;16(6):463-74. doi: 10.1016/j.ccr.2009.10.016. Cancer Cell. 2009. PMID: 19962665 Free PMC article.
36 results