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Function of the ABC transporters, P-glycoprotein, multidrug resistance protein and breast cancer resistance protein, in minimal residual disease in acute myeloid leukemia.
van der Pol MA, Broxterman HJ, Pater JM, Feller N, van der Maas M, Weijers GW, Scheffer GL, Allen JD, Scheper RJ, van Loevezijn A, Ossenkoppele GJ, Schuurhuis GJ. van der Pol MA, et al. Among authors: weijers gw. Haematologica. 2003 Feb;88(2):134-47. Haematologica. 2003. PMID: 12604403
Immunologic purging of autologous peripheral blood stem cell products based on CD34 and CD133 expression can be effectively and safely applied in half of the acute myeloid leukemia patients.
Feller N, van der Pol MA, Waaijman T, Weijers GW, Westra G, Ossenkoppele GJ, Schuurhuis GJ. Feller N, et al. Among authors: weijers gw. Clin Cancer Res. 2005 Jul 1;11(13):4793-801. doi: 10.1158/1078-0432.CCR-05-0031. Clin Cancer Res. 2005. PMID: 16000576 Free article. Clinical Trial.
High percentage of CD34-positive cells in autologous AML peripheral blood stem cell products reflects inadequate in vivo purging and low chemotherapeutic toxicity in a subgroup of patients with poor clinical outcome.
Feller N, Schuurhuis GJ, van der Pol MA, Westra G, Weijers GW, van Stijn A, Huijgens PC, Ossenkoppele GJ. Feller N, et al. Among authors: weijers gw. Leukemia. 2003 Jan;17(1):68-75. doi: 10.1038/sj.leu.2402781. Leukemia. 2003. PMID: 12529662 Clinical Trial.